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首页> 外文OA文献 >Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis.
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Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis.

机译：麻疹和亚急性硬化性全脑炎病毒蛋白：亚急性硬化性全脑炎患者缺乏M蛋白抗体。

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摘要

Studies on the immunoprecipitation of the proteins of several different measles and subacute sclerosing panencephalitis (SSPE) virus strains from lysates of infected cells have revealed a relative lack of antibodies to the nonglycosylated viral membrane protein (M) in the sera of patients with SSPE, in contrast to a high level of antibodies to other viral proteins. No evidence was found for the existence of a large number of antigenically unique M proteins. In contrast to SSPE sera, other hyperimmune human or rabbit sera precipitated M protein as well as the other viral proteins. The results suggest that in patients with SSPE there is either diminished synthesis of M, or it is not recognized normally by the immune system, and that an abnormality in M protein is involved in the pathogenesis of SSPE. Although differences in electrophoretic mobility of the M proteins and several other viral proteins were observed among different SSPE and measles strains, there was no pattern characteristic of SSPE strains, nor could these strains be distinguished by peptide mapping.
机译：对几种不同的麻疹和亚急性硬化性全脑炎（SSPE）病毒株从感染细胞的裂解物中免疫沉淀的研究表明，在SSPE患者的血清中相对缺乏针对非糖基化病毒膜蛋白（M）的抗体。与其他病毒蛋白的高水平抗体形成鲜明对比。没有证据表明存在大量抗原独特的M蛋白。与SSPE血清相反，其他超免疫的人或兔血清沉淀M蛋白以及其他病毒蛋白。结果表明，SSPE患者要么M合成减少，要么被免疫系统正常识别，并且M蛋白异常与SSPE的发病有关。尽管在不同的SSPE和麻疹菌株之间观察到M蛋白和几种其他病毒蛋白在电泳迁移率上的差异，但没有SSPE菌株的模式特征，也无法通过肽图分析来区分这些菌株。

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